Orthodontic Tooth Movement in the Osteoporotic Rat Maxilla by Local Application of Human Parathyroid Hormone
허현아, 박수현, 이현선, 이원, 윤현중, 표성운,
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허현아 ( Heo Hyun-A ) - Catholic University College of Medicine Department of Dentistry
박수현 ( Park Su-Hyun ) - Catholic University College of Medicine Department of Dentistry Division of Advanced General Dentistry
이현선 ( Lee Hyun-Sun ) - Catholic University Graduate School Department of Dentistry
이원 ( Lee Won ) - Catholic University College of Medicine Department of Dentistry Division Oral and Maxillofacial Surgery
윤현중 ( Yoon Hyun-Joong ) - Catholic University College of Medicine Department of Dentistry Division Oral and Maxillofacial Surgery
표성운 ( Pyo Sung-Woon ) - Catholic University College of Medicine Department of Dentistry Division Oral and Maxillofacial Surgery
Abstract
This study aimed to investigate the effect of parathyroid hormone (PTH) on tooth movement in an osteoporotic rat by comparing of the tooth movement distances and histologic observation. Fifteen, 8-week-old female rats were classified into three groups (n=5, respectively): (1) sham-operated control group, (2) ovariectomized group (OVX), and (3) ovariectomized rats injected with 30 μg/kg of PTH group (PTH). To induce the orthodontic tooth movement, a closedcoil spring appliance was placed and activated with the continuous force of 50 cN to the maxillary first molar. During the experimental period, the amount of tooth movement was measured at 7, 14, 21 days and all rats were sacrificed for histologic specimen preparation. The OVX group showed the fastest tooth movement, and the distance of tooth movement in the OVX group was significantly greater than that in the other two groups at 14 and 21 days (P=0.00 and P=0.02, respectively). The histologic sections revealed the evidence of osteopenia in both the OVX and PTH than the control group. And there was tendency to enhanced bone turnover in the inter-radicular bone of the PTH group. In summary, PTH treatment did not promote tooth movement in the osteoporotic rat model but showed the increased bone turnover. Therefore, further study is required to consider the clinical application of PTH during orthodontic treatment.
키워드
Osteoporosis; Parathyroid hormone; Orthodontics; Tooth movement
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